Dr. Patrick Butaye

About

Prof. Dr. Patrick Butaye, DVM, PhD, is working on several research subjects including antimicrobial resistance and alternatives for antimicrobials, mainly focusing on bacteriophages. He is PI of 2 major externally funded research projects on which 3 PhD students are active. Next to that, he is PI of an externally funded research project on the influences of β-glucans on the general immunity and works together with a post doc examining microbiomes of mongoose as well as methicillin resistance in the staphylococci of monkeys.

Dr. Butaye is involved as collaborator in 9 externally funded research projects in other countries all over the world on different subjects dealing mainly with zoonotic pathogens. He supports several intramural grants. He is an executive committee member of the European Study Group in Veterinary Medicine (ESGVM) of the European Society of Clinical Microbiology and Infectious diseases (ECMID) as well as a country Ambassador for the American Society for Microbiology (ASM). Next he is member of the scientific committee of the newly erected European College of veterinary Microbiology (ECVM), is assigned as expert on antimicrobial resistance in zoonotic pathogens for the WHO and FAO and facilitates PAHO meetings on antimicrobial resistance, antimicrobial use and mitigation of antimicrobial resistance.

Currently, Dr. Butaye has close to 170 Pubmed listed publications and over 250 publications in total (excluding conference contributions). His mid 2019 h-index is 44 and last year he had over 750 citations of his papers. He is Editor in Chief on ‘BMC Veterinary Research’ as well as ‘Veterinary sciences’. He is also editor of Frontiers in Microbiology and PlosOne.  

Publications

  1. Argudin, M. A. and P. Butaye, 2016. Dissemination of metal resistance genes among animal methicillin-resistant coagulase-negative Staphylococci. Research in veterinary science, 105, 192-194. 
  2. Argudin, M. A., B. Lauzat, B. Kraushaar, P. Alba, Y. Agerso, L. Cavaco, P. Butaye, M. C. Porrero, A. Battisti, B. A. Tenhagen, A. Fetsch and B. Guerra, 2016: Heavy metal and disinfectant resistance genes among livestock-associated methicillin-resistant Staphylococcus aureus isolates. Veterinary microbiology, 191, 88-95. 
  3. Butaye, P., M. A. Argudín and T. C. Smith, 2016: Livestock-Associated MRSA and its current evolution. Current Clinical Microbiology Reports, 3, 19-31. 
  4. Larsen, J., M. Stegger, P. S. Andersen, A. Petersen, A. R. Larsen, H. Westh, Y. Agerso, A. Fetsch, B. Kraushaar, A. Kasbohrer, A. T. Febetaler, S. Schwarz, C. Cuny, W. Witte, P. Butaye, O. Denis, M. Haenni, J. Y. Madec, E. Jouy, F. Laurent, A. Battisti, A. Franco, P. Alba, C. Mammina, A. Pantosti, M. Monaco, J. A. Wagenaar, E. de Boer, E. van Duijkeren, M. Heck, L. Dominguez, C. Torres, M. Zarazaga, L. B. Price and R. L. Skov, 2016: Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus. Clin Infect Dis. 63:1349-1352. 
  5. Malhotra-Kumar, S., B. B. Xavier, A. J. Das, C. Lammens, P. Butaye and H. Goossens, 2016: Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid. The Lancet. Infectious diseases. 16:283-284. 
  6. Michiels, T., S. Welby, M. Vanrobaeys, C. Quinet, L. Rouffaer, L. Lens, A. Martel and P. Butaye, 2016: Prevalence of Mycoplasma gallisepticum and Mycoplasma synoviae in commercial poultry, racing pigeons and wild birds in Belgium. Avian pathology. 45, 244-252. 
  7. Callens B, Haesebrouck F, Dewulf J, Boyen F, Butaye P, Catry B, Wattiau P, De Graef E. 2016. Risk of colistin resistance on the rise, Vlaams Diergeneeskundig Tijdschrift, 85: 36-40. 
  8. Peeters, L. E., E. Daeseleire, M. Devreese, G. Rasschaert, A. Smet, J. Dewulf, M. Heyndrickx, H. Imberechts, F. Haesebrouck, P. Butaye and S. Croubels, 2016: Residues of chlortetracycline, doxycycline and sulfadiazine-trimethoprim in intestinal content and feces of pigs due to cross-contamination of feed. BMC veterinary research, 12, 209. 
  9. Verhegghe, M., F. Crombe, K. Luyckx, F. Haesebrouck, P. Butaye, L. Herman, M. Heyndrickx and G. Rasschaert, 2016: Prevalence and Genetic Diversity of Livestock-Associated Methicillin-Resistant Staphylococcus aureus on Belgian Pork. Journal of food protection, 79, 82-89. 
  10. Xavier, B. B., C. Lammens, R. Ruhal, S. Kumar-Singh, P. Butaye, H. Goossens and S. Malhotra-Kumar, 2016: Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016. Euro surveillance. 21(27). 
  11. Xavier BB, Lammens C, Butaye P, Goossens H, Malhotra-Kumar S. 2016. Complete sequence of an IncFII plasmid harbouring the colistin resistance gene mcr-1 isolated from Belgian pig farms. J Antimicrob Chemother. 71(8):2342-4. 
  12. Sharma M, Nunez-Garcia J, Kearns AM, Doumith M, Butaye PR, Argudín MA, Lahuerta-Marin A, Pichon B, AbuOun M, Rogers J, Ellis RJ, Teale C, Anjum MF. 2016. Livestock-Associated Methicillin Resistant Staphylococcus aureus (LA-MRSA) Clonal Complex (CC) 398 Isolated from UK Animals belong to European Lineages. Front Microbiol. 7:1741. 
  13. Oosterik LH, Tuntufye HN, Tsonos J, Luyten T, Noppen S, Liekens S, Lavigne R, Butaye P, Goddeeris BM. 2016. Bioluminescent avian pathogenic Escherichia coli for monitoring colibacillosis in experimentally infected chickens. Vet J., 216:87-92. 
  14. Peeters, L. E. J., De Mulder, T., Van Coillie, E., Huygens, J., Smet, A., Daeseleire, E., Rasschaert, G., Butaye, P. (2017). Selection and transfer of an IncI1-tet(A) plasmid of Escherichia coli in an ex vivo model of the porcine caecum at doxycycline concentrations caused by cross contaminated feed. J Appl Microbiol, 123(5), 1312-1320. doi:10.1111/jam.13561. 
  15. Peeters LEJ, Croubels S, Rasschaert G, Imberechts H, Daeseleire E, Dewulf J, Heyndrickx M, Butaye P, Haesebrouck F, Smet A. 2017. Effect of residual doxycycline concentrations on resistance selection and transfer in porcine commensal Escherichia coli. Int J Antimicrob Agents. 51:123-127. 
  16. Pardon, B., Smet, A., Butaye, P., Argudin, M. A., Valgaeren, B., Catry, B., Deprez, P. (2017). Nosocomial Intravascular Catheter Infections with Extended-spectrum Beta-lactamase-producing Escherichia coli in Calves after Strain Introduction from a Commercial Herd. Transbound Emerg Dis, 64(1), 130-136. doi:10.1111/tbed.12352 
  17. Yassin, A. K., Zhang, J., Wang, J., Chen, L., Kelly, P., Butaye, P., Wang, C. (2017). Identification and characterization of mcr mediated colistin resistance in extraintestinal Escherichia coli from poultry and livestock in China. FEMS Microbiol Lett. 364(24). doi:10.1093/femsle/fnx242 
  18. Zhang, J., Wang, J., Chen, L., Yassin, A. K., Kelly, P., Butaye, P., Wang, C. (2017). Housefly (Musca domestica) and blow fly (Protophormia terraenovae) as vectors of colistin resistance genes-carrying bacteria. Appl Environ Microbiol. 84:e01736-17. 
  19. Butaye, P., & Wang, C. (2018). Colistin resistance, beyond the current knowledge. EBioMedicine. 34:16-17. doi:https://doi.org/10.1016/j.ebiom.2018.08.002 
  20. Chen, L., Zhang, J., Wang, J., Butaye, P., Kelly, P., Li, M., Wang, C. (2018). Newly identified colistin resistance genes, mcr-4 and mcr-5, from upper and lower alimentary tract of pigs and poultry in China. PLoS One, 13(3), e0193957. doi:10.1371/journal.pone.0193957 
  21. Hathcock, T., Poudel, A., Kang, Y., Butaye, P., Raiford, D., Mobley, T., Bellah, J. (2018). Multidrug-resistant Escherichia coli and Tetracycline-resistant Enterococcus faecalis in Wild Raptors of Alabama and Georgia, USA. J Wildl Dis. 55:482-487. doi:10.7589/2018-05-139 
  22. Peeters, L. E. J., Croubels, S., Rasschaert, G., Imberechts, H., Daeseleire, E., Dewulf, J., Butaye, P., Smet, A. (2018). Effect of residual doxycycline concentrations on resistance selection and transfer in porcine commensal Escherichia coli. Int J Antimicrob Agents, 51(1), 123-127. doi:10.1016/j.ijantimicag.2017.04.018 
  23. Qiu, H., Gong, J., Butaye, P., Lu, G., Huang, K., Zhu, G., Wang, C. (2018). CRISPR/Cas9/sgRNA-mediated targeted gene modification confirms the cause-effect relationship between gyrA mutation and quinolone resistance in Escherichia coli. FEMS Microbiol Lett. doi:10.1093/femsle/fny127 
  24. Vanrompay, D., Nguyen, T. L. A., Cutler, S. J., & Butaye, P. (2018). Antimicrobial Resistance in Chlamydiales, Rickettsia, Coxiella, and Other Intracellular Pathogens. Microbiol Spectr, 6(2). doi:10.1128/microbiolspec.ARBA-0003-2017 
  25. Zhang, J., Chen, L., Wang, J., Butaye, P., Huang, K., Qiu, H.,Wang, C. (2018). Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs. BMC Res Notes, 11(1), 143. doi:10.1186/s13104-018-3255-3. 
  26. Zhang J, Chen L, Wang J, Yassin AK, Butaye P, Kelly P, Gong J, Guo W, Li J, Li M, Yang F, Feng Z, Jiang P, Song C, Wang Y, You J, Yang Y, Price S, Qi K, Kang Y, Wang C. 2018. Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry. Sci Rep. 8(1):3705. 
  27. Argudin, M. A., Hoefer, A., & Butaye, P. (2019). Heavy metal resistance in bacteria from animals. Res Vet Sci, 122, 132-147. doi:10.1016/j.rvsc.2018.11.007. 
  28. Mebkhout, F, Mezali, L, Hamdi, T, Cantekin, Z, Ergun, Y, Ramdani-Bouguessa, N, & Butaye, P. 2019. Prevalence and distribution of staphylococcal enterotoxin genes among Staphylococcus aureus isolates from chicken and turkey carcasses in Algeria. Journal of the Hellenic Veterinary Medical Society, 69: 1297-1304. 
  29. Guardabassi L., Moodley A., Williams A., Stegger M., Damborg P., Halliday-Simmonds I. and Butaye P. 2019. High Prevalence of USA300 Among Clinical Isolates of Methicillin-Resistant Staphylococcus aureus on St. Kitts and Nevis, West Indies. Front Microbiol. 10:1123. 
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